Article

Murine limb ischaemia induces structural and functional remodelling of local and distant bone marrow

2025-09-18

Abstract excerpt

Peripheral arterial disease (PAD) can induce bone marrow (BM) ischaemia, although little is known about the implications of this for local and systemic haematopoiesis. We explored the impact of murine unilateral hind-limb ischaemia (HLI) surgery on the structure and function of the ischaemic and non-ischaemic BM, versus control mice without HLI surgery. Abnormal BM hypoxia was present in the ischaemic limb 7-days...

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Literature Corpus work: 1ce40988-8dad-520b-bce2-a938a455afe6
DOI: 10.1101/2025.09.16.676622

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