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Article

Osteonecrosis in Sickle Cell Disease.

Southern medical journal - 1 Sept 2016

Naseer Zan A, Bachabi Malick, Jones Lynne C, Sterling Robert S, Khanuja Harpal S

Abstract excerpt

Osteonecrosis is one of the most devastating musculoskeletal manifestations of sickle cell disease and most commonly affects the femoral head. Although the exact pathophysiology of this condition in patients with sickle cell disease is unknown, it is suggested that red cell sickling and repetitive vaso-occlusion may be associated with tissue hypoxia, inflammation, and subsequent bone necrosis and collapse. If...

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Identifiers

PMID: 27598354
DOI: 10.14423/SMJ.0000000000000516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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