Sex-specific gene and pathway modeling of inherited glioma risk.

doi:10.1093/neuonc/noy135

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Article

Sex-specific gene and pathway modeling of inherited glioma risk.

Neuro-oncology - 1 Jan 2019

Ostrom Quinn T, Coleman Warren, Huang William, Rubin Joshua B, Lathia Justin D, Berens Michael E, Speyer Gil, Liao Peter, Wrensch Margaret R, Eckel-Passow Jeanette E, Armstrong Georgina, Rice Terri, Wiencke John K, McCoy Lucie S, Hansen Helen M, Amos Christopher I, Bernstein Jonine L, Claus Elizabeth B, Houlston Richard S, Il'yasova Dora, Jenkins Robert B, Johansen Christoffer, Lachance Daniel H, Lai Rose K, Merrell Ryan T, Olson Sara H, Sadetzki Siegal, Schildkraut Joellen M, Shete Sanjay, Andersson Ulrika, Rajaraman Preetha, Chanock Stephen J, Linet Martha S, Wang Zhaoming, Yeager Meredith, Melin Beatrice, Bondy Melissa L, Barnholtz-Sloan Jill S

Abstract excerpt

Background: To date, genome-wide association studies (GWAS) have identified 25 risk variants for glioma, explaining 30% of heritable risk. Most histologies occur with significantly higher incidence in males, and this difference is not explained by currently known risk factors. A previous GWAS identified sex-specific glioma risk variants, and this analysis aims to further elucidate risk variation by sex using...

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PMID: 30124908
DOI: 10.1093/neuonc/noy135
PMCID: PMC6303471

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EGFR
TERT

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