Article
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
Scientific reports - 9 May 2018
Ostrom Quinn T, Kinnersley Ben, Wrensch Margaret R, Eckel-Passow Jeanette E, Armstrong Georgina, Rice Terri, Chen Yanwen, Wiencke John K, McCoy Lucie S, Hansen Helen M, Amos Christopher I, Bernstein Jonine L, Claus Elizabeth B, Il'yasova Dora, Johansen Christoffer, Lachance Daniel H, Lai Rose K, Merrell Ryan T, Olson Sara H, Sadetzki Siegal, Schildkraut Joellen M, Shete Sanjay, Rubin Joshua B, Lathia Justin D, Berens Michael E, Andersson Ulrika, Rajaraman Preetha, Chanock Stephen J, Linet Martha S, Wang Zhaoming, Yeager Meredith, Houlston Richard S, Jenkins Robert B, Melin Beatrice, Bondy Melissa L, Barnholtz-Sloan Jill S
Abstract excerpt
Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and...
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