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Article

Variation in CACNA1C is Associated with Amygdala Structure and Function in Adolescents.

Journal of child and adolescent psychopharmacology - 1 Nov 2015

Sumner Jennifer A, Sheridan Margaret A, Drury Stacy S, Esteves Kyle C, Walsh Kate, Koenen Karestan C, McLaughlin Katie A

Abstract excerpt

OBJECTIVE: Genome-wide association studies have identified allelic variation in CACNA1C as a risk factor for multiple psychiatric disorders associated with limbic system dysfunction, including bipolar disorder, schizophrenia, and depression. The CACNA1C gene codes for a subunit of L-type voltage-gated calcium channels, which modulate amygdala function. Although CACNA1C genotype appears to be associated with...

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Identifiers

PMID: 26401721
DOI: 10.1089/cap.2015.0047
PMCID: PMC4653820

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