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Article

The Iceberg Map of germline mutations in childhood cancer: focus on primary immunodeficiencies.

Current opinion in pediatrics - 1 Dec 2018

Kindler Oliver, Quehenberger Franz, Benesch Martin, Seidel Markus G

Abstract excerpt

PURPOSE OF REVIEW: The risk of cancer is higher, and its outcome is worse in patients with primary immunodeficiency (PID) than in members of the general population. Thus, the inter-relationship of malignant diseases with PIDs requires more study. RECENT FINDINGS: Large genetic screens identified a vast number of germline mutations in childhood cancer patient samples. Although TP53 was the most frequent single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30124581
DOI: 10.1097/MOP.0000000000000680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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