Article
Repression of simian virus 40 early transcription by viral DNA replication in human 293 cells.
Nature - 1 Jan 2000
Lewis E D, Manley J L
Abstract excerpt
The small DNA tumour virus simian virus 40 (SV40) has served as an excellent model for many studies on the mechanism and control of gene expression in eukaryotic cells. The SV40 early region produces two protein products. One product (large-T antigen) is known both to repress early viral transcription and to stimulate viral replication by binding to specific sites in the origin-promoter region. The early promoter...
Topics
- Adenoviridae
- Antigens, Viral, Tumor
- Cell Line
- DNA Replication
- Gene Expression Regulation
- HeLa Cells
- Humans
- Mutation
- Plasmids
- Promoter Regions, Genetic
- Simian virus 40
- Transfection