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The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis

20 Feb 2016

Abstract excerpt

We have previously reported that RORγ expression was decreased in ER-ve breast cancer, and increased expression improves clinical outcomes. However, the underlying RORγ dependent mechanisms that repress breast carcinogenesis have not been elucidated. Here we report that RORγ negatively regulates the oncogenic TGF-β/EMT and mammary stem cell (MaSC) pathways, whereas RORγ positively regulates DNA-repair. We...

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PMID: 27211549
DOI: 10.1016/j.ebiom.2016.02.028

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