Article

Rare Cancer-Associated Mutations Target the AF1 Phosphoregulatory Domain of RARγ

2026-08-19

Abstract excerpt

Abstract Background/Objectives: Retinoic acid receptor γ (RARγ), encoded by RARG, is increas-ingly recognized as a cancer-associated regulator through aberrant expression in multiple solid tumors and recurrent gene rearrangements in acute myeloid leukemia. While the on-cogenic relevance of RARγ is well established, the potential involvement of its N-terminal activation function-1 (AF1) domain in human cancer remai...

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Literature Corpus work: 8b4a868b-263d-573f-8070-511456115833
DOI: 10.20944/preprints202608.1286.v1

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