Article
In a pilot study, reduced fatty acid desaturase 1 function was associated with nonalcoholic fatty liver disease and response to treatment in children.
Pediatric research - 1 Nov 2018
Nobili Valerio, Alisi Anna, Liu Zhipeng, Liang Tiebing, Crudele Annalisa, Raponi Massimiliano, Lin Jingmei, Chalasani Naga P, Liu Wanqing
Abstract excerpt
BACKGROUND: FADS1 gene encodes delta 5 desaturase, a rate-limiting enzyme in the metabolism of n-3 and n-6 polyunsaturated fatty acids (PUFAs). Minor alleles of FADS1 locus polymorphisms are associated with reduced FADS1 expression and intra-hepatic fat accumulation. However, the relationship between FADS1 expression and pediatric nonalcoholic fatty liver disease (NAFLD) risk remains to be explored. METHODS: We...
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