Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activated hepatic stellate cells directly induce pathogenic Th17 cells in chronic hepatitis B virus infection.

Experimental cell research - 1 Oct 2017

Liu Yun, Li Lei, Liu Jiang, She Wei-Min, Shi Jie-Min, Li Jing, Wang Ji-Yao, Jiang Wei

Abstract excerpt

Th17 cells are involved in liver fibrosis by activating hepatic stellate cells (HSCs). We aimed to investigate whether HSCs are able to regulate the function of Th17 cells and to determine the relevant mechanism. Sixty-five patients diagnosed with chronic hepatitis B (CHB) were enrolled in this study. To determine the effect of HSCs on T cells, naïve CD4+T cells and Th17 cells were sorted from CHB patients and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to Cyclooxygenase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dinoprostone

Share to Hepatic Stellate Cells

Share to Hepatitis B, Chronic

Share to Interleukin-1beta

Share to Interleukin-6

Share to Th17 Cells

Source

Identifiers

PMID: 28780305
DOI: 10.1016/j.yexcr.2017.08.001

Genes

CCL20
CCR6
RORC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activated hepatic stellate cells directly induce pathogenic Th17 cells in chronic hepatitis B virus infection.PMID 28780305Read ↗

HSCs-derived exosomes regulate the levels of inflammatory cytokines in HIBECs through miR-122-5p mediated p38 MAPK signaling pathwaySemantic proximity Read ↗

Activated Hepatic Stellate Cells Induce Infiltration and Formation of CD163+ Macrophages via CCL2/CCR2 PathwaySemantic proximity Read ↗

Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice.Semantic proximity Read ↗

CD38+HLA-DR+CD8+ T Cells induced by IL-15 exert liver injury through NKG2D in chronic hepatitis B cirrhosisSemantic proximity Read ↗

Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitisSemantic proximity Read ↗

Changes in circulating Foxp3(+) regulatory T cells and interleukin-17-producing T helper cells during HBV-related acute-on-chronic liver failure.Semantic proximity Read ↗

Expression of hepatic stellate cell activation-related genes in HBV-, HCV-, and nonalcoholic fatty liver disease-associated fibrosisSemantic proximity Read ↗

IL-17 Signaling in Primary Sclerosing Cholangitis Patient-Derived OrganoidsSemantic proximity Read ↗

Hepatic Stellate Cells Preferentially Induce Foxp3+ Regulatory T Cells by Production of Retinoic AcidSemantic proximity Read ↗

Targeting Hepatic Stellate Cells for the Prevention and Treatment of Liver Cirrhosis and Hepatocellular Carcinoma: Strategies and Clinical TranslationSemantic proximity Read ↗

Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis.Semantic proximity Read ↗

Involvement of Interleukin 6 in Hepatitis B Viral Infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.