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Article

Reprogramming of pro-inflammatory human macrophages to an anti-inflammatory phenotype by bile acids.

Scientific reports - 10 Jan 2018

Wammers Marianne, Schupp Anna-Kathrin, Bode Johannes G, Ehlting Christian, Wolf Stephanie, Deenen René, Köhrer Karl, Häussinger Dieter, Graf Dirk

Abstract excerpt

Cholestasis is caused by autoimmune reactions, drug-induced hepatotoxicity, viral infections of the liver and the obstruction of bile ducts by tumours or gallstones. Cholestatic conditions are associated with impaired innate and adaptive immunity, including alterations of the cellular functions of monocytes, macrophages, NK cells and T-cells. Bile acids act as signalling molecules, affecting lipopolysaccharide...

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Identifiers

PMID: 29321478
DOI: 10.1038/s41598-017-18305-x
PMCID: PMC5762890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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