Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies.

Leukemia - 1 Sept 2012

Damm F, Nguyen-Khac F, Fontenay M, Bernard O A

Abstract excerpt

Spliceosome mutations represent a new generation of acquired genetic alterations that affect both myeloid and lymphoid malignancies. A substantial proportion of patients with myelodysplastic syndromes (MDSs) or chronic lymphocytic leukemia (CLL) harbor such mutations, which are often missense in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to NOTCH1 gene
Share to Leukemia, Lymphocytic, Chronic, B-Cell
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myelodysplastic Syndromes

Share to Myeloproliferative Disorders

Share to RNA Splicing

Share to Spliceosomes

Source

Identifiers

PMID: 22484420
DOI: 10.1038/leu.2012.86

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22484420-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies.PMID 22484420Read ↗

Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia.Semantic proximity Read ↗

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis.Semantic proximity Read ↗

Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis.Semantic proximity Read ↗

Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms.Semantic proximity Read ↗

The significance of spliceosome mutations in chronic lymphocytic leukemia.Semantic proximity Read ↗

Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes.Semantic proximity Read ↗

The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes.Semantic proximity Read ↗

Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome.Semantic proximity Read ↗

Spliceosome mutations in hematopoietic malignancies.Semantic proximity Read ↗

Mutations in spliceosome genes and therapeutic opportunities in myeloid malignanciesSemantic proximity Read ↗

[Hematological malignancies driven by aberrant splicing].Semantic proximity Read ↗

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.