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Article

SF3B1K700E rewires splicing of cell cycle regulators.

RNA (New York, N.Y.) - 17 Feb 2026

Baker Mai, Engal Eden, Sharma Aveksha, Petasny Mayra, Jaffe-Herman Shiri, Geminder Ophir, Su Minhua, Bentata Mercedes, Gershon Adi, Kay Gillian, Salton Maayan

Abstract excerpt

Pre-mRNA splicing plays a crucial role in maintaining cellular homeostasis, with strict regulation required for processes such as cell cycle progression. SF3B1, a core component of the spliceosome, has emerged as a key player in alternative splicing regulation and is frequently mutated in cancer. Among these mutations, SF3B1K700E disrupts normal splicing patterns and deregulates cell cycle control. Here we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41443830
DOI: 10.1261/rna.080661.125
PMCID: PMC12908452

Genes

ARPP19
SF3B1
DYRK1A
ECT2
ENSA
STAG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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