Article
Identification of Positively and Negatively Selected Driver Gene Mutations Associated With Colorectal Cancer With Microsatellite Instability.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2018
Jonchere Vincent, Marisa Laetitia, Greene Malorie, Virouleau Alain, Buhard Olivier, Bertrand Romane, Svrcek Magali, Cervera Pascale, Goloudina Anastasia, Guillerm Erell, Coulet Florence, Landman Samuel, Ratovomanana Toky, Job Sylvie, Ayadi Mira, Elarouci Nabila, Armenoult Lucile, Merabtene Fatiha, Dumont Sylvie, Parc Yann, Lefèvre Jérémie H, André Thierry, Fléjou Jean-François, Guilloux Agathe, Collura Ada, de Reyniès Aurélien, Duval Alex
Abstract excerpt
Background & Aims: Recent studies have shown that cancers arise as a result of the positive selection of driver somatic events in tumor DNA, with negative selection playing only a minor role, if any. However, these investigations were concerned with alterations at nonrepetitive sequences and did not take into account mutations in repetitive sequences that have very high pathophysiological relevance in the tumors...
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