The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts.

doi:10.3389/fimmu.2018.01788

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Article

The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts.

Frontiers in immunology - 1 Jan 2018

Recke Andreas, Konitzer Sarah, Lemcke Susanne, Freitag Miriam, Sommer Nele Maxi, Abdelhady Mohammad, Amoli Mahsa M, Benoit Sandrine, El-Chennawy Farha, Eldarouti Mohammad, Eming Rüdiger, Gläser Regine, Günther Claudia, Hadaschik Eva, Homey Bernhard, Lieb Wolfgang, Peitsch Wiebke K, Pföhler Claudia, Robati Reza M, Saeedi Marjan, Sárdy Miklós, Sticherling Michael, Uzun Soner, Worm Margitta, Zillikens Detlef, Ibrahim Saleh, Vidarsson Gestur, Schmidt Enno

Abstract excerpt

IgG3 is the IgG subclass with the strongest effector functions among all four IgG subclasses and the highest degree of allelic variability among all constant immunoglobulin genes. Due to its genetic position, IgG3 is often the first isotype an antibody switches to before IgG1 or IgG4. Compared with the other IgG subclasses, it has a reduced half-life which is probably connected to a decreased affinity to the...

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PMID: 30116249
DOI: 10.3389/fimmu.2018.01788
PMCID: PMC6082936

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