Identification of IgG3-specific epitope that remedies problem in diagnostic IgG subclass determination due to human genetic variation.

Abstract excerpt

There are four subtypes of human IgG with different effector functions. Quantifying the relative amount of each IgG subtype is important for laboratory diagnosis in multiple settings. However, in an evolving landscape of the appreciation of human variability and the need for precision/personalised laboratory diagnosis, it has also been shown that there are numerous natural variants of IgG subtypes, with at least...

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