Synstable Fusion: A Network-Based Algorithm for Estimating Driver Genes in Fusion Structures.

Abstract excerpt

Gene fusion structure is a class of common somatic mutational events in cancer genomes, which are often formed by chromosomal mutations. Identifying the driver gene(s) in a fusion structure is important for many downstream analyses and it contributes to clinical practices. Existing computational approaches have prioritized the importance of oncogenes by incorporating prior knowledge from gene networks. However,...

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