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Article

Rational Design of Thermostable Carbonic Anhydrase Mutants Using Molecular Dynamics Simulations.

The journal of physical chemistry. B - 13 Sept 2018

Parra-Cruz Ricardo, Jäger Christof M, Lau Phei Li, Gomes Rachel L, Pordea Anca

Abstract excerpt

The stability of enzymes is critical for their application in industrial processes, which generally require different conditions from the natural enzyme environment. Both rational and random protein engineering approaches have been used to increase stability, with the latter requiring extensive experimental effort for the screening of variants. Moreover, some general rules addressing the molecular origin of...

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Identifiers

PMID: 30114369
DOI: 10.1021/acs.jpcb.8b05926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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