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Article

Computational analysis of the effect of Gly100Ala mutation on the thermostability of SazCA.

Journal of biomolecular structure & dynamics - 1 Jan 2023

Kumar Shashi, Biswas Soumya, Deshpande Parag A

Abstract excerpt

Maintaining the protein stability upon mutation is a challenging task in protein engineering. In the present computational study, we induced a single point Gly100Ala mutation in SazCA and examined the factors governing the stability and flexibility of the mutated form, and compared it to that of the wildtype using molecular dynamics simulations. We observed higher structural stability and lesser residual mobility...

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PMID: 36744540
DOI: 10.1080/07391102.2023.2175259

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