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Article

Molecular dynamics simulations suggest stabilizing mutations in a de novo designed α/β protein.

Protein engineering, design & selection : PEDS - 31 Dec 2019

Gill Matthew, McCully Michelle E

Abstract excerpt

Designing functional proteins that can withstand extreme heat is beneficial for industrial and protein therapeutic applications. Thus, elucidating the atomic-level determinants of thermostability is a major interest for rational protein design. To that end, we compared the structure and dynamics of a set of previously designed, thermostable proteins based on the activation domain of human procarboxypeptidase A2...

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Identifiers

PMID: 32086513
DOI: 10.1093/protein/gzaa005
PMCID: PMC7052480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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