Article
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.
PLoS genetics - 1 Apr 2017
Folkersen Lasse, Fauman Eric, Sabater-Lleal Maria, Strawbridge Rona J, Frånberg Mattias, Sennblad Bengt, Baldassarre Damiano, Veglia Fabrizio, Humphries Steve E, Rauramaa Rainer, de Faire Ulf, Smit Andries J, Giral Philippe, Kurl Sudhir, Mannarino Elmo, Enroth Stefan, Johansson Åsa, Enroth Sofia Bosdotter, Gustafsson Stefan, Lind Lars, Lindgren Cecilia, Morris Andrew P, Giedraitis Vilmantas, Silveira Angela, Franco-Cereceda Anders, Tremoli Elena, Gyllensten Ulf, Ingelsson Erik, Brunak Søren, Eriksson Per, Ziemek Daniel, Hamsten Anders, Mälarstig Anders
Abstract excerpt
Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the...
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