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Article

ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma.

Oncogene - 8 Dec 2011

Singh R R, Kunkalla K, Qu C, Schlette E, Neelapu S S, Samaniego F, Vega F

Abstract excerpt

Successful treatment of diffuse large B-cell lymphoma (DLBCL) is frequently hindered by the development of resistance to conventional chemotherapy resulting in disease relapse and high mortality. High expression of antiapoptotic and/or drug transporter proteins induced by oncogenic signaling pathways has been implicated in the development of chemoresistance in cancer. Previously, our studies showed that high...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 1
Share to Cinnamates

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Tolerance

Share to Hedgehog Proteins

Share to Lymphoma, Large B-Cell, Diffuse

Share to Oncogene Proteins

Share to Stromal Cells

Share to Zinc Finger Protein GLI1

Source

Open in PubMed Open full text

Identifiers

PMID: 21625222
DOI: 10.1038/onc.2011.195
PMCID: PMC3165099

Genes

ABCG2
BCL2
GLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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