Article
E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Mar 2019
Godwin Tanis D, Kelly S Thomas, Brew Tom P, Bougen-Zhukov Nicola M, Single Andrew B, Chen Augustine, Stylianou Cassie E, Harris Lawrence D, Currie Sophie K, Telford Bryony J, Beetham Henry G, Evans Gary B, Black Michael A, Guilford Parry J
Abstract excerpt
BACKGROUND: The E-cadherin gene (CDH1) is frequently mutated in diffuse gastric cancer and lobular breast cancer, and germline mutations predispose to the cancer syndrome Hereditary Diffuse Gastric Cancer. We are taking a synthetic lethal approach to identify druggable vulnerabilities in CDH1-mutant cancers. METHODS: Density distributions of cell viability data from a genome-wide RNAi screen of isogenic MCF10A...
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