Article
Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination.
Nature neuroscience - 1 May 2016
He Danyang, Marie Corentine, Zhao Chuntao, Kim Bongwoo, Wang Jincheng, Deng Yaqi, Clavairoly Adrien, Frah Magali, Wang Haibo, He Xuelian, Hmidan Hatem, Jones Blaise V, Witte David, Zalc Bernard, Zhou Xin, Choo Daniel I, Martin Donna M, Parras Carlos, Lu Q Richard
Abstract excerpt
Mutations in CHD7, encoding ATP-dependent chromodomain helicase DNA-binding protein 7, in CHARGE syndrome lead to multiple congenital anomalies, including craniofacial malformations, neurological dysfunction and growth delay. Mechanisms underlying the CNS phenotypes remain poorly understood. We found that Chd7 is a direct transcriptional target of oligodendrogenesis-promoting factors Olig2 and Smarca4/Brg1 and is...
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