Article
Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import.
Human molecular genetics - 1 Feb 2020
Di Pardo Alba, Monyror John, Morales Luis Carlos, Kadam Vaibhavi, Lingrell Susanne, Maglione Vittorio, Wozniak Richard W, Sipione Simonetta
Abstract excerpt
Brain cholesterol homeostasis is altered in Huntington's disease (HD), a neurodegenerative disorder caused by the expansion of a CAG nucleotide repeat in the HTT gene. Genes involved in the synthesis of cholesterol and fatty acids were shown to be downregulated shortly after the expression of mutant huntingtin (mHTT) in inducible HD cells. Nuclear levels of the transcription factors that regulate lipid...
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