Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD ‐conditioned media‐induced mechanical sensitivity

Abstract excerpt

Background: Low back pain is a major contributor to disability worldwide and generates a tremendous socioeconomic impact. The degenerative intervertebral disc (IVD) has been hypothesized to contribute to discogenic pain by sensitizing nociceptive neurons innervating the disc to stimuli that is nonpainful in healthy patients. Previously, we demonstrated the ability of degenerative IVDs to sensitize neurons to...

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