Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in CEP68 gene associated with risk of immediate selective reactions to non-steroidal anti-inflammatory drugs.

The pharmacogenomics journal - 1 Apr 2019

Perkins James R, Acosta-Herrera Marialbert, Plaza-Serón María C, Jurado-Escobar Raquel, Doña Inmaculada, García-Martín Elena, Isidoro-García María, Bartra Joan, Ribas-Perez David, Mayorga Cristobalina, Torres María J, Flores Carlos, Cornejo-García José A

Abstract excerpt

Non-steroidal anti-inflammatory drugs (NSAIDs) are the main triggers of drug hypersensitivity reactions. Such reactions can be pharmacologically or immunologically mediated, but in both cases individual susceptibility can be influenced by genetic factors. Polymorphisms in centrosomal protein of 68 kDa (CEP68) have been associated with pharmacologically mediated NSAIDs reactions. Here, we evaluated this gene in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphylaxis
Share to Anti-Inflammatory Agents, Non-Steroidal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Hypersensitivity

Share to Genetic Association Studies

Share to Inflammation

Share to Microtubule-Associated Proteins

Share to Risk Factors

Share to Urticaria

Source

Identifiers

PMID: 30093714
DOI: 10.1038/s41397-018-0038-0

Genes

CEP68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in CEP68 gene associated with risk of immediate selective reactions to non-steroidal anti-inflammatory drugs.PMID 30093714Read ↗

Variants of CEP68 gene are associated with acute urticaria/angioedema induced by multiple non-steroidal anti-inflammatory drugs.Semantic proximity Read ↗

Genome-wide and follow-up studies identify CEP68 gene variants associated with risk of aspirin-intolerant asthma.Semantic proximity Read ↗

Advanced phenotyping in hypersensitivity drug reactions to NSAIDs.Semantic proximity Read ↗

Genetic basis of hypersensitivity reactions to nonsteroidal anti-inflammatory drugsSemantic proximity Read ↗

Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review.Semantic proximity Read ↗

Oxidative stress and genetic susceptibility to cross-reactive and selective NSAID hypersensitivitySemantic proximity Read ↗

What we know about nonsteroidal anti-inflammatory drug hypersensitivity.Semantic proximity Read ↗

Genetic Variants of Thymic Stromal Lymphopoietin in Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria/Angioedema.Semantic proximity Read ↗

Nonsteroidal anti-inflammatory drug-induced acute urticaria/angioedema associated with atopy-related genes' genetic variants.Semantic proximity Read ↗

Genetic variants of the arachidonic acid pathway in non-steroidal anti-inflammatory drug-induced acute urticaria.Semantic proximity Read ↗

Deep sequencing of prostaglandin-endoperoxide synthase (PTGE) genes reveals genetic susceptibility for cross-reactive hypersensitivity to NSAID.Semantic proximity Read ↗

Hypersensitivity reactions to non-steroidal anti-inflammatory drugs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.