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Article

Genetic Variants of Thymic Stromal Lymphopoietin in Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria/Angioedema.

International archives of allergy and immunology - 1 Jan 2016

Plaza-Serón María Del Carmen, Blanca-López Natalia, Pérez-Sánchez Natalia, Doña Inmaculada, Acosta-Herrera Marialbert, Pino-Yanes María, Flores Carlos, Cornejo-García José Antonio, Perkins James R, Molina Ana, Torres Maria José, Blanca Miguel, Canto María Gabriela, Ayuso Pedro

Abstract excerpt

BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequent agents involved in hypersensitivity drug reactions, with NSAID-induced urticaria and/or angioedema (NIUA) being the most common entity. Mast cells are key players in NIUA and are activated by thymic stromal lymphopoietin (TSLP). This cytokine functions through recognition by its receptor, composed of IL7Rα (interleukin-7 receptor...

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Identifiers

PMID: 27240835
DOI: 10.1159/000444797

Genes

TSLP

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