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Article

Nonsteroidal anti-inflammatory drug-induced acute urticaria/angioedema associated with atopy-related genes' genetic variants.

The Journal of allergy and clinical immunology - 1 Feb 2026

Jiménez-Sánchez Isabel María, Jurado-Escobar Raquel, Doña Inmaculada, Sáenz de Santa María Rocío, Núñez Rafael, Triano-Cornejo José, Cortés-Collado Juan J, Laguna José J, Loli-Ausejo David, Vega-Rioja Antonio, López-Sánchez José D, Torres María J, Cornejo-García José A

Abstract excerpt

BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most consumed medicines worldwide and the main drug hypersensitivity triggers. The most common type is bred by pharmacologic cyclooxygenase-1 (COX-1) inhibition, after chemically unrelated NSAID intake, and NSAID-induced acute urticaria/angioedema (NIUA) is the most frequent clinical phenotype, with patients being frequently sensitized...

Topics

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Angioedema
Anti-Inflammatory Agents, Non-Steroidal
Case-Control Studies
Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Hypersensitivity

Source

Identifiers

PMID: 41276223
DOI: 10.1016/j.jaci.2025.11.005

Genes

FCER1A
IL13
IL3
IL4
IL5
IL9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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