Article
Hypersensitivity reactions to non-steroidal anti-inflammatory drugs.
Current drug metabolism - 1 Nov 2009
Cornejo-Garcia José Antonio, Blanca-López Natalia, Doña Inmaculada, Andreu Inmaculada, Agúndez José A G, Carballo Miguel, Blanca Miguel, Canto María Gabriela
Abstract excerpt
NSAIDs are the most important group of drugs involved in hypersensitivity drug reactions, and include heterogeneous compounds with very different chemical structures. These reactions can be IgE dependent (immediate reactions), T cell-mediated (non-immediate), or induced by a non-specific immunological mechanism related with the blocking of the COX-1 enzyme and the shunting to the lipooxygenase pathway...
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