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The clinicopathological and prognostic significances of CDC73 expression in breast cancer: A pathological and bioinformatics analysis.

Histology and histopathology - 1 Apr 2023

E Ying, Xue Hang, Zhang Cong-Yu, Zhao Ming-Zhen, Zheng Hua-Chuan

Abstract excerpt

Parafibromin is a protein encoded by the oncosuppressor CDC73 gene, whose mutation results in hyperparathyroidism-jaw tumor syndrome (HPT-JT) and parathyroid carcinoma. Down-regulation of parafibromin is linked to lung, gastric, colorectal, and ovarian cancer tumorigenesis. Parafibromin expression was detected by RT-PCR, bioinformatics analysis, Western blot, and immunohistochemistry; and compared with...

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PMID: 36255176
DOI: 10.14670/HH-18-534

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