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Article

Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3.

Nature communications - 8 Aug 2018

Scietti Luigi, Chiapparino Antonella, De Giorgi Francesca, Fumagalli Marco, Khoriauli Lela, Nergadze Solomon, Basu Shibom, Olieric Vincent, Cucca Lucia, Banushi Blerida, Profumo Antonella, Giulotto Elena, Gissen Paul, Forneris Federico

Abstract excerpt

Lysyl hydroxylases catalyze hydroxylation of collagen lysines, and sustain essential roles in extracellular matrix (ECM) maturation and remodeling. Malfunctions in these enzymes cause severe connective tissue disorders. Human lysyl hydroxylase 3 (LH3/PLOD3) bears multiple enzymatic activities, as it catalyzes collagen lysine hydroxylation and also their subsequent glycosylation. Our understanding of LH3 functions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosyltransferases

Share to Hydroxylation

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Share to Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase

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Source

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Identifiers

PMID: 30089812
DOI: 10.1038/s41467-018-05631-5
PMCID: PMC6082870

Genes

PLOD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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