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Article

The structural basis for the collagen processing by human P3H1/CRTAP/PPIB ternary complex.

Nature communications - 8 Sept 2024

Li Wenguo, Peng Junjiang, Yao Deqiang, Rao Bing, Xia Ying, Wang Qian, Li Shaobai, Cao Mi, Shen Yafeng, Ma Peixiang, Liao Rijing, Qin An, Zhao Jie, Cao Yu

Abstract excerpt

Collagen posttranslational processing is crucial for its proper assembly and function. Disruption of collagen processing leads to tissue development and structure disorders like osteogenesis imperfecta (OI). OI-related collagen processing machinery includes prolyl 3-hydroxylase 1 (P3H1), peptidyl-prolyl cis-trans isomerase B (PPIB), and cartilage-associated protein (CRTAP), with their structural organization and...

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Identifiers

PMID: 39245686
DOI: 10.1038/s41467-024-52321-6
PMCID: PMC11381544

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The structural basis for the collagen processing by human P3H1/CRTAP/PPIB ternary complex.PMID 39245686Read ↗

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