Article
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.
Nature communications - 6 Feb 2018
Guo Hou-Fu, Tsai Chi-Lin, Terajima Masahiko, Tan Xiaochao, Banerjee Priyam, Miller Mitchell D, Liu Xin, Yu Jiang, Byemerwa Jovita, Alvarado Sarah, Kaoud Tamer S, Dalby Kevin N, Bota-Rabassedas Neus, Chen Yulong, Yamauchi Mitsuo, Tainer John A, Phillips George N, Kurie Jonathan M
Abstract excerpt
Collagen lysyl hydroxylases (LH1-3) are Fe2+- and 2-oxoglutarate (2-OG)-dependent oxygenases that maintain extracellular matrix homeostasis. High LH2 levels cause stable collagen cross-link accumulations that promote fibrosis and cancer progression. However, developing LH antagonists will require structural insights. Here, we report a 2 Å crystal structure and X-ray scattering on dimer assemblies for the LH...
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