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Article

Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrix.

The Journal of biological chemistry - 9 Oct 2009

Risteli Maija, Ruotsalainen Heli, Salo Antti M, Sormunen Raija, Sipilä Laura, Baker Naomi L, Lamandé Shireen R, Vimpari-Kauppinen Leena, Myllylä Raili

Abstract excerpt

Lysyl hydroxylase 3 (LH3) is a multifunctional enzyme possessing lysyl hydroxylase, collagen galactosyltransferase, and glucosyltransferase (GGT) activities. We report here an important role for LH3 in the organization of the extracellular matrix (ECM) and cytoskeleton. Deposition of ECM was affected in heterozygous LH3 knock-out mouse embryonic fibroblasts (MEF(+/-)) and in skin fibroblasts collected from a...

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Identifiers

PMID: 19696018
DOI: 10.1074/jbc.M109.038190
PMCID: PMC2788872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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