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Article

Hypertension-causing cullin 3 mutations disrupt COP9 signalosome binding.

American journal of physiology. Renal physiology - 1 Jan 2020

Cornelius Ryan J, Yang Chao-Ling, Ellison David H

Abstract excerpt

The discovery of new genetic mutations that cause hypertension has illuminated previously unrecognized physiological pathways. One such regulatory pathway was identified when mutations in with no lysine kinase (WNK)4, Kelch-like 3 (KLHL3), and cullin 3 (CUL3) were shown to cause the disease familial hyperkalemic hypertension (FHHt). Mutations in all three genes upregulate the NaCl cotransporter (NCC) due to an...

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Identifiers

PMID: 31813255
DOI: 10.1152/ajprenal.00497.2019
PMCID: PMC6985821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hypertension-causing cullin 3 mutations disrupt COP9 signalosome binding.PMID 31813255Read ↗

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