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Article

WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.

Biochemical and biophysical research communications - 23 Sept 2017

Susa Koichiro, Sohara Eisei, Takahashi Daiei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi

Abstract excerpt

WNK-OSR1/SPAK-NCC signaling cascade is important for regulating salt balance and blood pressure. Activation of WNK-OSR1/SPAK-NaCl cotransporter (NCC) cascade increases sodium reabsorption in the kidney, leading to pseudohypoaldosteronism type II (PHA II) characterized by salt-sensitive hypertension and hyperkalemia. It has been previously demonstrated that the amount of phosphorylated and total NCC markedly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28743496
DOI: 10.1016/j.bbrc.2017.07.121

Genes

WNK4
OSR1
WNK1
KLHL3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

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WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.PMID 28743496Read ↗

Generation and analysis of pseudohypoaldosteronism type II knock-in mice caused by a nonsense KLHL3 mutation in the Kelch domain.Semantic proximity Read ↗

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.Semantic proximity Read ↗

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivoSemantic proximity Read ↗

SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.Semantic proximity Read ↗

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.Semantic proximity Read ↗

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.Semantic proximity Read ↗

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.Semantic proximity Read ↗

KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.Semantic proximity Read ↗

Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse modelsSemantic proximity Read ↗

WNK kinases regulate thiazide-sensitive Na-Cl cotransport.Semantic proximity Read ↗

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.Semantic proximity Read ↗

Life and death of the distal nephron: WNK4 and NCC as major players.Semantic proximity Read ↗

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