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Article

Lipocalin-2 abrogates epithelial cell cycle arrest by PPARγ inhibition.

Laboratory investigation; a journal of technical methods and pathology - 1 Nov 2018

Jung Michaela, Brüne Bernhard, von Knethen Andreas, Guiteras Roser, Cruzado Josep Maria, Hotter Georgina, Sola Anna

Abstract excerpt

Macrophage-epithelial cross-talk regulates cell cycle progression and represents an important factor in rescuing epithelial cells from cell cycle arrest in order to maintain a healthy epithelial phenotype. However, the underlying mechanisms are still not well defined. We provide evidence that macrophage-secreted lipocalin-2 (Lcn-2) plays a key role during this process. In a co-culture setup using cell cycle...

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Identifiers

PMID: 30087458
DOI: 10.1038/s41374-018-0098-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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