Article
Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways.
The Journal of cell biology - 28 Aug 2006
Wang Jiahu, Wang Ningning, Xie Jinling, Walton Staci C, McKown Robert L, Raab Ronald W, Ma Peisong, Beck Shannon L, Coffman George L, Hussaini Isa M, Laurie Gordon W
Abstract excerpt
Renewal of nongermative epithelia is poorly understood. The novel mitogen "lacritin" is apically secreted by several nongermative epithelia. We tested 17 different cell types and discovered that lacritin is preferentially mitogenic or prosecretory for those types that normally contact lacritin during its glandular outward flow. Mitogenesis is dependent on lacritin's C-terminal domain, which can form an...
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