Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells

25 Nov 2015

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with the worst survival rates and least effective treatments. Moreover, total deaths due to PDAC are predicted to increase in the next 15 years. Therefore, novel insights into basic mechanism of PDAC development and therapies are needed. PDAC is characterized by a complex microenvironment, in which cancer and stromal cells release...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine and Purinergic Signaling
Share to Cancer, Stress, Anesthesia, and Immune Response
Share to Sulfur Compounds in Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26607222
DOI: 10.1186/s12943-015-0472-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cellsPMID 26607222Read ↗

Extracellular ATP drives pancreatic cancer cell invasion via purinergic receptor-integrin interactionsSemantic proximity Read ↗

Identification of MRP4/ABCC4 as a Target for Reducing the Proliferation of Pancreatic Ductal Adenocarcinoma Cells by Modulating the cAMP EffluxSemantic proximity Read ↗

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives.Semantic proximity Read ↗

Altered Potassium Channels in Pancreatic Ductal Adenocarcinoma: Mechanisms, Implications, and Therapeutic OpportunitiesSemantic proximity Read ↗

ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survivalSemantic proximity Read ↗

Blockades Adenosine Receptor 2B Suppresses Pancreatic Adenocarcinoma Progression by Inhibiting Leukemia Inhibitory Factor Secretion from MacrophagesSemantic proximity Read ↗

TRPM2 promotes the proliferation and invasion of pancreatic ductal adenocarcinomaSemantic proximity Read ↗

ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward?Semantic proximity Read ↗

ATP6AP2 is robustly expressed in pancreatic β cells and neuroendocrine tumors, and plays a role in maintaining cellular viabilitySemantic proximity Read ↗

Ca2+ Signaling and ATP Production in Pancreatic Cancer.Semantic proximity Read ↗

P2X7 Receptor in Hematological MalignanciesSemantic proximity Read ↗

Annexin A1 contributes to pancreatic cancer cell phenotype, behaviour and metastatic potential independently of Formyl Peptide Receptor pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.