Article
Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers.
Cancer discovery - 1 Feb 2017
Olsen Sarah Naomi, Wronski Ania, Castaño Zafira, Dake Benjamin, Malone Clare, De Raedt Thomas, Enos Miriam, DeRose Yoko S, Zhou Wenhui, Guerra Stephanie, Loda Massimo, Welm Alana, Partridge Ann H, McAllister Sandra S, Kuperwasser Charlotte, Cichowski Karen
Abstract excerpt
Luminal breast cancers are typically estrogen receptor-positive and generally have the best prognosis. However, a subset of luminal tumors, namely luminal B cancers, frequently metastasize and recur. Unfortunately, the causal events that drive their progression are unknown, and therefore it is difficult to identify individuals who are likely to relapse and should receive escalated treatment. Here, we identify a...
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