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Article

CLCA2 Interactor EVA1 Is Required for Mammary Epithelial Cell Differentiation

1 Mar 2016

Abstract excerpt

CLCA2 is a p53-, p63-inducible transmembrane protein that is frequently downregulated in breast cancer. It is induced during differentiation of human mammary epithelial cells, and its knockdown causes epithelial-to-mesenchymal transition (EMT). To determine how CLCA2 promotes epithelial differentiation, we searched for interactors using membrane dihybrid screening. We discovered a strong interaction with the cell...

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PMID: 26930581
DOI: 10.1371/journal.pone.0147489

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