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Article

EFA6B Antagonizes Breast Cancer

13 Aug 2014

Abstract excerpt

One of the earliest events in epithelial carcinogenesis is the dissolution of tight junctions and cell polarity signals that are essential for normal epithelial barrier function. Here, we report that EFA6B, a guanine nucleotide exchange factor for the Ras superfamily protein Arf6 that helps assemble and stabilize tight junction, is required to maintain apico-basal cell polarity and mesenchymal phenotypes in...

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PMID: 25115298
DOI: 10.1158/0008-5472.can-14-0298

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