Article

ZEB2 Regulates Endocrine Therapy Sensitivity and Metastasis in Luminal A Breast Cancer Through a Non-Canonical Mechanism

2021-04-14

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose: </bold>The transcription factors ZEB1 and ZEB2 mediate epithelial-to-mesenchymal transition (EMT) and metastatic progression in numerous malignancies including breast cancer. ZEB1 and ZEB2 drive EMT through transcriptional repression of cell-cell junction proteins and members of the tumor suppressive miR200 family. However, in estrogen receptor positive (ER+) breast cance...

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Literature Corpus work: 91db9098-999d-5e7d-a191-b17e4d16d8ad
DOI: 10.21203/rs.3.rs-390171/v1

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