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Article

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin.

Nature communications - 7 Aug 2018

Hines Rochelle M, Maric Hans Michael, Hines Dustin J, Modgil Amit, Panzanelli Patrizia, Nakamura Yasuko, Nathanson Anna J, Cross Alan, Deeb Tarek, Brandon Nicholas J, Davies Paul, Fritschy Jean-Marc, Schindelin Hermann, Moss Stephen J

Abstract excerpt

Fast inhibitory synaptic transmission is mediated by γ-aminobutyric acid type A receptors (GABAARs) that are enriched at functionally diverse synapses via mechanisms that remain unclear. Using isothermal titration calorimetry and complementary methods we demonstrate an exclusive low micromolar binding of collybistin to the α2-subunit of GABAARs. To explore the biological relevance of collybistin-α2-subunit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30087324
DOI: 10.1038/s41467-018-05481-1
PMCID: PMC6081406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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