Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses.

Journal of cell science - 15 Aug 2011

Tyagarajan Shiva K, Ghosh Himanish, Harvey Kirsten, Fritschy Jean-Marc

Abstract excerpt

Collybistin (CB) is a guanine-nucleotide-exchange factor (GEF) selectively activating Cdc42. CB mutations cause X-linked mental retardation due to defective clustering of gephyrin, a postsynaptic protein associated with both glycine and GABA(A) receptors. Using a combination of biochemistry and cell biology we provide novel insights into the roles of the CB2 splice variants, CB2(SH3+) and CB2(SH3-), and their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to cdc42 GTP-Binding Protein
Share to GABAergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Protein Engineering

Share to Protein Isoforms

Share to Protein Multimerization

Share to Rho Guanine Nucleotide Exchange Factors

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 21807943
DOI: 10.1242/jcs.086199
PMCID: PMC3148131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses.PMID 21807943Read ↗

PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering.Semantic proximity Read ↗

The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering.Semantic proximity Read ↗

Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin.Semantic proximity Read ↗

Human ARHGEF9 intellectual disability syndrome is phenocopied by a mutation that disrupts collybistin binding to the GABAA receptor α2 subunit.Semantic proximity Read ↗

Gephyrin-mediated γ-aminobutyric acid type A and glycine receptor clustering relies on a common binding site.Semantic proximity Read ↗

Complex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversitySemantic proximity Read ↗

Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb.Semantic proximity Read ↗

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin.Semantic proximity Read ↗

Development of a floxed <i>Gabbr2</i> gene allows for widespread conditional disruption of GABBR2 and recapitulates the phenotype of germline Gabbr2 knockout miceSemantic proximity Read ↗

Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes.Semantic proximity Read ↗

Differential protein structural disturbances and suppression of assembly partners produced by nonsense GABRG2 epilepsy mutations: implications for disease phenotypic heterogeneity.Semantic proximity Read ↗

GABA(A) receptor gamma 2 subunit mutations linked to human epileptic syndromes differentially affect phasic and tonic inhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.