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Article

GABA(A) receptor gamma 2 subunit mutations linked to human epileptic syndromes differentially affect phasic and tonic inhibition.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Dec 2007

Eugène Emmanuel, Depienne Christel, Baulac Stéphanie, Baulac Michel, Fritschy Jean Marc, Le Guern Eric, Miles Richard, Poncer Jean Christophe

Abstract excerpt

GABA acts on GABA(A) receptors to evoke both phasic inhibitory synaptic events and persistent, tonic currents. The gamma2 subunit of the GABA(A) receptor is involved in both phasic and tonic signaling in the hippocampus. Several mutations of this subunit are linked to human epileptic syndromes with febrile seizures, yet it is not clear how they perturb neuronal activity. Here, we examined the expression and...

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Identifiers

PMID: 18094250
DOI: 10.1523/JNEUROSCI.2618-07.2007
PMCID: PMC6673514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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