Article
Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot.
RNA (New York, N.Y.) - 1 Feb 2022
Jones Christopher P, Ferré-D'Amaré Adrian R
Abstract excerpt
SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 Å-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the...
Topics
- Codon, Terminator
- Crystallography, X-Ray
- Frameshifting, Ribosomal
- Models, Molecular
- Mutation
- Nucleic Acid Conformation
- RNA, Viral
- SARS-CoV-2