Article
Comparative studies of frameshifting and nonframeshifting RNA pseudoknots: a mutational and NMR investigation of pseudoknots derived from the bacteriophage T2 gene 32 mRNA and the retroviral gag-pro frameshift site.
RNA (New York, N.Y.) - 1 Aug 2002
Wang Yue, Wills Norma M, Du Zhihua, Rangan Anupama, Atkins John F, Gesteland Raymond F, Hoffman David W
Abstract excerpt
Mutational and NMR methods were used to investigate features of sequence, structure, and dynamics that are associated with the ability of a pseudoknot to stimulate a -1 frameshift. In vitro frameshift assays were performed on retroviral gag-pro frameshift-stimulating pseudoknots and their derivatives, a pseudoknot from the gene 32 mRNA of bacteriophage T2 that is not naturally associated with frameshifting, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.